મૂર્ખને કઈ પેરે સમજવું, એને નિશ્ચે નરકમાં જવું.

mūrkhanē kaī pērē samajavuṁ, ēnē niścē narakamāṁ javuṁ.

Literally: How can a fool be made to understand; he is destined to go to hell.
What it means: Attempting to reason with a foolish person is futile because they are set on their self-destructive path.

Also said as

ગુજરાતી કહેવતસંગ્રહ (Gujarati Kahevat Sangrah) (1921) · read from the scan by machine — the Gujarati itself is unchecked · English is machine-made and nobody has checked it yet

Heard it differently, or know we've got the sense wrong? Tell us — that is exactly the kind of correction this needs.